Description / Ephrin-A1
EphrinA1, also known as B61, LERK1, and EFL1, is a member of the Ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The A-class ligands have a GPI anchor following the conserved sequence. EphrinA1 binds EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse EphrinA1 share 85% amino acid identity. Only membranebound or Fc -clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. Nearly all receptors and ligands are expressed in developing and adult neural tissue. The Eph/Ephrin families also appear to play a role in angiogenesis.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#6D31) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Ephrin-A1. |
| Antigen | recombinant mouse protein Ephrin-A1 |
| Application | WB |
| Synonyms | Efna1; B61; Efl1; Epl1; Eplg1; Lerk1; AI325262 |
| Uniprot ID | P52793 |
| Protein RefSeq | NP_034237.3 |
| mRNA RefSeq | NM_010107.4 |