Description / Dkk-4
Dickkopf related protein 4 (Dkk4) is a member of the Dkk protein family that includes Dkk1, 2, 3, and 4. All four members are secreted proteins that are synthesized as precursor proteins with an Nterminal signal peptide and 2 conserved cysteinerich domains, which are separated by a linker region. Dkk proteins have potential furin type proteolytic cleavage sites, and short forms of Dkk2 and Dkk4 containing only the second cysteine-rich domain can be generated by proteolytic processing. Dkk proteins have distinct patterns of expression in adult and embryonic tissues, suggesting that they may play diverse roles in these tissues. The Dkk proteins have distinct effects on Wnt signaling. Dkk1 and Dkk4 are Wnt antagonists. Dkk3 has not been demonstrated to affect Wnt signaling, and Dkk2 acts as an agonist or antagonist, depending on the cellular context.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#9M19) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Recombinant human Dkk-4 |
| Application | WB, Capture Ab |
| Synonyms | Dickkopf-related protein 4, Dickkopf-4; Dkk-4; hDkk-4, Dickkopf-related protein 4 short form |
| Uniprot ID | Q9UBT3 |
| Protein RefSeq | NP_055235.1 |
| mRNA RefSeq | NM_014420.2 |