Description / Chitinase 3-like 1
Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells, vascular smooth muscle cells, and hepatic stellate cells. The biological function of YKL-40 is unclear. It is not known to have a specific receptor. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas and asthma
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG1 |
| Clone Nr. | (#9X24) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Human recombinant Chitinase 3-like 1 |
| Application | E |
| Synonyms | 39 kDa synovial protein, Cartilage glycoprotein 39 (CGP-39; GP-39; hCGP-39), YKL-40 |
| Uniprot ID | P36222 |
| Protein RefSeq | NP_001267.2 |
| mRNA RefSeq | NM_001279.2 |