Description / Chem R23
ChemR23, also known as Dez in mouse, is a seven-pass transmembrane, G-protein-associated receptor related to the chemoattractant C3a and C5a complement receptors. Although it shows less than 30% amino acid identity to the chemokine receptor family, it shows significant structural similarity. ChemR23 expression is limited to macrophages and dendritic cells. A ligand for ChemR23 has been identified as Chemerin, also known as Tig-2. Receptor-ligand binding elicits chemotaxis of macrophages and immature, but not mature, dendritic cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#6A30) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Chem R23. |
| Antigen | human recombinant Chem R23 |
| Application | FC |
| Synonyms | CMKLR1; DEZ; ChemR23; CHEMERINR |
| Uniprot ID | Q99788 |
| Protein RefSeq | NP_001135815.1 |
| mRNA RefSeq | NM_001142343.1 |