Description / CD58
CD58, also known as lymphocyte function-associated antigen (LFA-3) is a cell-bound immunoglobulin superfamily receptor with only one known ligand, CD2. CD58 is widely expressed on human hematopoietic and non-hematopoietic tissues, leukocytes, erythrocytes, endothelial and epithelial cells, and fibroblasts. The engagement of CD58 with CD2 optimizes immune recognition and initiates T cell expansion and activation. These contact activities can occur between helper T cells and antigen-presenting cells and cytolytic effectors and target cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#8G24) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CD58 extracellular domain (also called LFA-3). |
| Antigen | human recombinant CD585 extracellular domain |
| Application | WB, FC |
| Synonyms | CD58; ag3; LFA3; LFA-3 |
| Uniprot ID | P19256 |
| Protein RefSeq | NP_001770.1 |
| mRNA RefSeq | NM_001779.2 |