Description / CD244
2B4, also known as CD244, is a cell surface glycoprotein belonging to the CD2 subgroup of the immunoglobulin superfamily. It acts as a high-affinity receptor for CD48. It is expressed by natural killer (NK) cells and CD8+ T cell subsets. It can regulate killing by CD8+ T cells and NK cells, and IFN-gamma secretion by NK cells. It may also regulate NK cell and T cell proliferation.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#7D24) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human CD244 recombinant protein (extracellular domain). |
| Antigen | Human recombinant CD244 (EC domain) |
| Application | WB |
| Synonyms | CD244; 2B4; NAIL; Nmrk; NKR2B4; SLAMF4 |
| Uniprot ID | Q9BZW8 |
| Protein RefSeq | NP_057466 |
| mRNA RefSeq | NM_016382 |