Description / CD22, soluble
CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin's lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257). Recombinant human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.
More Information
| Size | 20 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | Determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 666 |
| Molecular Weight | 75 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKNTSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL NDSGQLGLRM ESKTEKWMER IHLNVSERPF PPHIQLPPEI QESQEVTLTC LLNFSCYGYP IQLQWLLEGV PMRQAAVTST SLTIKSVFTR SELKFSPQWS HHGKIVTCQL QDADGKFLSN DTVQLNVKHT PKLEIKVTPS DA |
| Synonyms | CD22; SIGLEC2; SIGLEC-2 |
| Uniprot ID | P20273 |
| Protein RefSeq | NP_001762.2 |
| mRNA RefSeq | NM_001771.3 |