Description / CD105/Endoglin
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-ß1 and ß3 with high affinity but not to TGF-ß2.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#12J11) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with cell membrane glycoproteins of lymphoblastic leukemia cells. IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity |
| Antigen | cell membrane glycoproteins of lymphoblastic leukemia cells |
| Application | IHC |
| Synonyms | Endoglin; END; ORW; HHT1; ORW1; CD105 |
| Uniprot ID | P17813 |
| Protein RefSeq | NP_000109 |
| mRNA RefSeq | NM_000118 |