Description / CCRL-2
Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently eleven CC-specific receptors designated CCR1 to CCR11. HCR (Human Chemokine Receptor), also known as CRAM, CKRX, and CCRL2, is a G protein-linked seven transmembrane domain spanning chemokine receptor that exists in two isoforms CRAM-A and CRAM-B. The two isoforms differ at the N-terminus with CRAM-A having an additional 12 amino acids. Cells reported to express HCR/CRAM include peripheral blood cells, monocytes, neutrophils, and T cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#5A15) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | CCRL-2 exists as two isoforms: CRAM-A and CRAM-B. This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCRL-2 (CRAM-A). |
| Antigen | recombinant human CCRL-2 |
| Application | FC |
| Synonyms | CCRL2; HCR; CKRX; CRAM; CRAM-A; CRAM-B |
| Uniprot ID | O00421 |
| Protein RefSeq | NP_003956.2 |
| mRNA RefSeq | NM_003965.4 |