Description / Amphiregulin
Amphiregulin is an EGF-related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Murine Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.
More Information
| Size | 50 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml. |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Length [aa] | 98 |
| Molecular Weight | 11.3 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | SVRVEQVIKP KKNKTEGEKS TEKPKRKKKG GKNGKGRRNK KKKNPCTAKF QNFCIHGECR YIENLEVVTC NCHQDYFGER CGEKSMKTHS EDDKDLSK |
| Synonyms | AR, AREG, Colorectum cell-derived growth factor (CRDGF) |
| Uniprot ID | P31955 |
| Protein RefSeq | NP_033834.1 |
| mRNA RefSeq | NM_009704.4 |