anti-human ADAM-10 monoclonal antibody Anti-Human 100 µg

In stock

Cat-Nr.
101-M205
Size
100 µg
  €533.00

Description / anti-human ADAM-10 monoclonal antibody

The monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer’s disease.

More Information

Size 100 µg
Source Mouse
Isotype IgG2
Biological Activity WB: 1:500-1000
Clone Nr. (#6D31)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human ADAM-10 (extracellular domain) recombinant protein.
Antigen recombinant human ADAM-10 (extracellular domain)
Application WB
Synonyms ADAM10; kuz; AD10; MADM; CD156c; HsT18717
Uniprot ID O14672
Protein RefSeq NP_001101.1
mRNA RefSeq NM_001110

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