Human Desmoglein-1, soluble
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| Cat-Nr. | 400-030 |
| Size | 50 µg |
| Price | p.i. € |
| Source | Insect cells |
| Label | GST-tag |
| Formulation | lyophilized |
| Length [aa] | 717 |
| Molecular Weight | 80 kDa |
| Species Reactivity | Human |
| Synonyms | DSG1; DG1; DSG; CDHF4; PPKS1; SPPK1 |
| Description | Desmoglein1 is one of three members of the desmoglein subfamily of calcium-dependent cadherin cell adhesion molecules. Together with desmocollins, another subfamily within the cadherin superfamily, the desmoglein isoforms form the adhesive components of desmosomes, the cel-lcell adhesive structures that are found in epithelial cells. Human Desmoglein1 is a type I transmembrane glycoprotein of 1049 amino acid (aa) residues with a 23 aa signal peptide and a 26 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, Desmoglein1 has R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tail of Desmoglein 1 interacts with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the Desmoglein1 with the intermediate filaments. Desmoglein1 has been shown to be important in establishing cellcell adhesion and function in the epidermis. In the autoimmune skin disease pemphigus foliaceus, autoantibodies to Desmoglein1 can cause the loss of keratinocyte adhesion resulting in blisters. |
| Protein Sequence | APEWIKFAAA CREGEDNSKR NPIAKIHSDC AANQQVTYRI SGVGIDQPPY GIFVINQKTG EINITSIVDR EVTPFFIIYC RALNSMGQDL ERPLELRVRV LDINDNPPVF SMATFAGQIE ENSNANTLVM ILNATDADEP NNLNSKIAFK IIRQEPSDSP MFIINRNTGE IRTMNNFLDR EQYGQYALAV RGSDRDGGAD GMSAECECNI KILDVNDNIP YMEQSSYTIE IQENTLNSNL LEIRVIDLDE EFSANWMAVI FFISGNEGNW FEIEMNERTN VGILKVVKPL DYEAMQSLQL SIGVRNKAEF HHSIMSQYKL KASAISVTVL NVIEGPVFRP GSKTYVVTGN MGSNDKVGDF VATDLDTGRP STTVRYVMGN NPADLLAVDS RTGKLTLKNK VTKEQYNMLG GKYQGTILSI DDNLQRTCTG TININIQSFG NDDRTNTEPN TKITTNTGRQ ESTSSTNYDT STTSTDSSQV YSSEPGNGAK DLLSDNVHFG PTRSPILGYW KIKGLVQPTR LLLEYLEEKY EEHLYERDEG DKWRNKKFEL GLEFPNLPYY IDGDVKLTQS MAIIRYIADK HNMLGGCPKE RAEISMLEGA VLDIRYGVSR IAYSKDFETL KVDFLSKLPE MLKMFEDRLC HKTYLNGDHV THPDFMLYDA LDVVLYMDPM CLDAFPKLVC FKKRIEAIPQ IDKYLKSSKY IAWPLQGWQA TFGGGDH |
| Uniprot ID | Q02413 |
| Protein RefSeq | NP_001933.2 |
| mRNA RefSeq | NM_001942.3 |
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