Human Endothelin-1/ET-1
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| Cat-Nr. | 200-017 |
| Size | 25 µg |
| Price | 410 € |
| Source | E. coli |
| Label | His-Tag |
| Formulation | lyophilized from PBS |
| Purity Confirmation | > 98% by SDS-PAGE & visualized Coomassie stain |
| Length [aa] | 204 |
| Molecular Weight | 26.0 kDa |
| Species Reactivity | Human |
| Buffer | PBS |
| Synonyms | Preproendothelin-1, PPET-1, ET-1, EDN1 |
| Description | Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases. |
| Protein Sequence | MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH |
| Uniprot ID | P05305 |
| Protein RefSeq | NP_001946.3 |
| mRNA RefSeq | NM_01955.4 |
Figures
SDS-PAGE analysis of recombinant human Endothelin-1. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.
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