Human IFN alpha 2a
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| Cat-Nr. | 100-446 |
| Size | 100 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 166 |
| Molecular Weight | 19.3 kDa |
| Endotoxin Levels | < 0.1 ng/ug of protein (< 1 EU/ug) |
| Biological Activity | Determined by a cytotoxicity assay using human TF-1 cells. |
| Species Reactivity | Human |
| Synonyms | Interferon alpha‐2, Interferon alpha A, Type I interferon |
| Description | Proteins of this family play an important role in inducing non‐specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFN‐β. Both IFNs have similar anti‐viral activity and regulate expression of MHC class I antigens. IFN‐α contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant Human IFN‐α (2a) is a 19.3 kDa protein containing 166 amino acid residues. |
| Protein Sequence | MCDLPQTHSL GSRRTLMLLA QMRKISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE |
| Uniprot ID | P01563 |
| Protein RefSeq | NP_000596.2 |
| mRNA RefSeq | NM_000605.4 |
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