Human Endostatin
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| Cat-Nr. | 100-334S |
| Size | 20 µg |
| Price | 95 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 184 |
| Molecular Weight | 20.2 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Measured by its ability to inhibit HUVEC migration. |
| Species Reactivity | Human |
| Synonyms | COL18A1; KS; KNO; KNO1 |
| Description | Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues. |
| Protein Sequence | MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK |
| Uniprot ID | P39060 |
| Protein RefSeq | NP_085059 |
| mRNA RefSeq | NM_030582 |
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