Human BD-4
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| Cat-Nr. | 100-331 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 50 |
| Molecular Weight | 6.0 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100 ng/ml. |
| Species Reactivity | Human |
| Synonyms | DEFB104A; BD-4; DEFB4; hBD-4; DEFB-4; DEFB104; DEFB104B |
| Description | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemo attractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues. |
| Protein Sequence | EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP |
| Uniprot ID | Q8WTQ1 |
| Protein RefSeq | NP_525128.2 |
| mRNA RefSeq | NM_080389.2 |
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