Human BMP-4
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| Cat-Nr. | 100-326H |
| Size | 5 µg |
| Price | 199 € |
| Source | HeLa cells |
| Formulation | lyophilized |
| Purity Confirmation | >97% by SDS-PAGE and HPLC anaylsis |
| Length [aa] | 113 |
| Molecular Weight | 25,6 kDa |
| Biological Activity | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml. |
| Species Reactivity | Human, Mouse, Rat |
| Synonyms | BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS7 |
| Description | Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein. |
| Protein Sequence | HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR |
| Uniprot ID | P12644 |
| Protein RefSeq | NP_001193 |
| mRNA RefSeq | NM_001202 |
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