Human BMP-13 / CDMP-2 (Animal Free)
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| Cat-Nr. | 100-137-AF |
| Size | 50 µg |
| Price | 230 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 120 |
| Molecular Weight | 27.0 kDa |
| Endotoxin Levels | Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) |
| Biological Activity | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.0-3.0 µg/ml. |
| Species Reactivity | Mouse, Human |
| Synonyms | GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6 |
| Description | BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino-acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. |
| Protein Sequence | TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR |
| Uniprot ID | P43028 |
| Protein RefSeq | NP_038554.1 |
| mRNA RefSeq | NM_013526.1 |
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