Human RANTES (CCL 5)
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| Cat-Nr. | 100-095 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 68 |
| Molecular Weight | 7.8 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml. |
| Species Reactivity | Cow, Hamster, Monkey, Mouse, Rat, Human, Leech, Bacteria |
| Synonyms | CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E |
| Description | RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
| Protein Sequence | SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS |
| Uniprot ID | P13501 |
| Protein RefSeq | NP_002976.2 |
| mRNA RefSeq | NM_002985 |
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