Human Pleiotrophin
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| Cat-Nr. | 100-094 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 136 |
| Molecular Weight | 15.4 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Data not available. |
| Species Reactivity | Mouse, Rat, Human, Chicken, Hamster, Bacteria |
| Reconstitution | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Stability and Storage | The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C. |
| Synonyms | PTN; HARP; HBNF; HBGF8; NEGF1 |
| Description | Human Pleiotrophin (PTN) also called HARP (Heparin affin-regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN and Midkine are structural homologs, and are highly conserved among species. PTN plays an important role in development processes and promotion of neurite extension. Recombinant Pleiotrophin is a 15.4 kDa protein consisting of 136 amino acid residues. |
| Protein Sequence | GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD |
| Uniprot ID | P21246 |
| Protein RefSeq | NP_002816.1 |
| mRNA RefSeq | NM_002825 |
Reference
- Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches. Li F. et al., J Biol Chem. 2010 Sep 3;285(36):27673-85.
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