Human MIP-4 (CCL18)
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| Cat-Nr. | 100-080 |
| Size | 10 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 68 |
| Molecular Weight | 7.8 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Assay #1: Determined by its ability to chemoattract human T lymphocytes using a concentration of 1.0 - 10.0 ng/ml. Assay #2: Determined by its ability to chemoattract human iDCs using a concentration of 1.0 - 10.0 ng/ml. |
| Species Reactivity | Human, Mouse, Bacteria |
| Stability and Storage | For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % HSA or 0.1% BSA) and store in working aliquots at -20°C to -80°C. Lyophilized MIP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -20°C. Upon reconstitution MIP-4 can be stored at 4°C between 2-7 days and for future use below -20°C. |
| Synonyms | Macrophage Inflammatory Protein-4, CCL18, PARC, DC-CK1, AMAC-1 |
| Description | MIP-4 is a CC chemokine that is expressed in lymph nodes, lungs, placenta and bone marrow. MIP-4’s primary receptor is unknown. MIP-4 chemoattracts lymphocytes, and has been shown to exert activity on both CD4+and CD8+ T cells. Recombinant human MIP-4 is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
| Protein Sequence | QVGTNKELC CLVYTSWQIP QKFLVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA |
| Uniprot ID | P55774 |
| Protein RefSeq | NP_002979 |
| mRNA RefSeq | NM_002988 |
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