Human MDC (67 aa)
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| Cat-Nr. | 100-069 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 67 |
| Molecular Weight | 8.0 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml. |
| Species Reactivity | Hamster, Mouse, Human |
| Synonyms | ADAM11; MDC |
| Description | MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
| Protein Sequence | YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ |
| Uniprot ID | O75078 |
| Protein RefSeq | NP_002381 |
| mRNA RefSeq | NM_002390 |
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