Human/Murine FGF-8B (Animal Free)
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| Cat-Nr. | 100-020-AF |
| Size | 25 µg |
| Price | 230 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 97% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 193 |
| Molecular Weight | 22.4 kDa |
| Endotoxin Levels | < 0.01 ng/ug of protein (< 0.1 EU/ug) |
| Biological Activity | Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 2.0-4.0 ng/ml. |
| Synonyms | FGF8; AIGF; KAL6; FGF-8; HBGF-8 |
| Description | FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues. |
| Protein Sequence | MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR |
| Uniprot ID | P55075 |
| Protein RefSeq | NP_149355 |
| mRNA RefSeq | NM_033165 |
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