Human Eotaxin-3 (CCL26)
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| Cat-Nr. | 100-014 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 71 |
| Molecular Weight | 8.4 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2 µg/ml. |
| Species Reactivity | Human |
| Synonyms | CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha |
| Description | Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
| Protein Sequence | TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L |
| Uniprot ID | Q9Y258 |
| Protein RefSeq | NP_006063 |
| mRNA RefSeq | NM_006072 |
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