Human BAFF (Animal Free)
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| Cat-Nr. | 100-002-AF |
| Size | 20 µg |
| Price | 230 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 153 |
| Molecular Weight | 17.0 kDa |
| Endotoxin Levels | < 0.01 ng/µg of protein (<0.1EU/µg) |
| Biological Activity | Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml. |
| Species Reactivity | Human |
| Synonyms | TNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF22 |
| Description | BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF. |
| Protein Sequence | AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL |
| Uniprot ID | Q9Y275 |
| Protein RefSeq | NP_006564.1 |
| mRNA RefSeq | NM_006573.4 |
Reference
- Increased B Cell-Activating Factor Promotes Tumor Invasion and Metastasis in Human Pancreatic Cancer. Mitsuhito Koizumi et al., PLoS One. 2013; 8(8): e71367.
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