Rabbit Anti-Human VE-Statin/EGFL7
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| Cat-Nr. | 102-PA14S |
| Size | 100 µg |
| Price | 185 € |
| Category | Polyclonal Antibody |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots. |
| Preparation | Produced from sera of rabbits immunised with highly pure recombinant human VE-Statin/EGFL7. Anti-human VE-Statin/EGFL7 was purified by Protein-A chromatography. |
| Antigen | Recombinant human EGFL7 |
| Application | WB, IHC |
| Synonyms | EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin |
| Description | EGFL7 (VE-Statin) is an ∼ 30 kDa secreted protein that contains an Emilin-like (EMI) domain (a multimerization motif), and two epidermal growth factor (EGF) domains, one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble like extracellular matrix (ECM) proteins and, thus, could incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses. |
| Uniprot ID | Q9UHF1 |
| Protein RefSeq | NP_057299.1 |
| mRNA RefSeq | NM_016215.4 |
Figures
Immunohistochemical staining (ICC) of human and mouse EGFL7.
Experiments were performed by N. Dudvarski Stankovic and other members of the research group „Molecular Signal Transduction“ of Prof. Dr. Mirko HH Schmidt, Institute of Microscopic Anatomy and Neurobiology, University Medical Center of Johannes Gutenberg University Mainz, Germany.
Immunohistochemical staining (IHC) of blood vessel endothelial cells in the white matter in human brain by anti-human EGFL7.
Experiments were performed by N. Dudvarski Stankovic and other members of the research group „Molecular Signal Transduction“ of Prof. Dr. Mirko HH Schmidt, Institute of Microscopic Anatomy and Neurobiology, University Medical Center of Johannes Gutenberg University Mainz, Germany.
Immunohistochemical staining (IHC) of blood vessel endothelial cells in the human fetal brain by anti-human EGFL7.
Experiments were performed by N. Dudvarski Stankovic and other members of the research group „Molecular Signal Transduction“ of Prof. Dr. Mirko HH Schmidt, Institute of Microscopic Anatomy and Neurobiology, University Medical Center of Johannes Gutenberg University Mainz, Germany.
Western Blot analysis of recombinant human VE-Statin, EGFL7/W15 mutant and EGFL7/WT using a polyclonal antibody directed against recombinant human EGFL7/WT produced in E. coli.
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