Rabbit Anti-Human TRAIL/Apo2L
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| Cat-Nr. | 102-PA11 |
| Size | 200 µg |
| Price | 305 € |
| Category | Polyclonal Antibody |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots. |
| Preparation | Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hsTRAIL/Apo2L. Anti-Human sTRAIL/Apo2L specific antibody was purified by affinity chromatography employing immobilized hsTRAIL/Apo2L matrix. |
| Antigen | recombinant human TRAIL/ApoL2 |
| Application | WB |
| Synonyms | TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L |
| Description | TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. |
| Uniprot ID | P50591 |
| Protein RefSeq | NP_003801.1 |
| mRNA RefSeq | NM_003810.3 |
Figures
Western Blot analysis with recombinant human sTRAIL/Apo2L. Samples were loaded in 15% SDS-polyacrylamide gel under reducing conditions.
Immunofluorescence staining of human foreskin (cryo-section of PFA-fixed tissue) with anti-human TRAIL/Apo2L (green; 5µg/ml). Nuclei were counter-stained with Dapi (blue).
The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany.
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