Armenian Hamster Anti-Mouse CD80
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| Cat-Nr. | 103-M144 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#MAB0713) |
| Isotype | IgG |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a Armenian Hamster immunized with recombinant Mouse CD80 protein. IgG fraction of the culture supernatant was purified by Protein G affinity chromatography. |
| Antigen | Recombinant Mouse CD80 protein |
| Application | IHC, FC |
| Synonyms | Cd80; B71; Ly53; TSA1; Cd28l; Ly-53; MIC17 |
| Description | B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily. |
| Uniprot ID | Q00609 |
| Protein RefSeq | NP_033985.3 |
| mRNA RefSeq | NM_009855.2 |
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